Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
JK Garrett, SC Jameson, B Thomson, MH Collins… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: IL-5 is a cytokine critically involved in regulating several aspects of
eosinophils including their production, activation, and tissue recruitment. As such, IL-5 may
be involved in the pathogenesis of hypereosinophilic syndromes, a group of poorly treated
diverse disorders characterized by sustained peripheral blood and/or tissue eosinophilia.
OBJECTIVE: We aimed to assess the safety and efficacy of a humanized blocking
monoclonal antibody against IL-5 (mepolizumab) in patients with several forms of hyper …
eosinophils including their production, activation, and tissue recruitment. As such, IL-5 may
be involved in the pathogenesis of hypereosinophilic syndromes, a group of poorly treated
diverse disorders characterized by sustained peripheral blood and/or tissue eosinophilia.
OBJECTIVE: We aimed to assess the safety and efficacy of a humanized blocking
monoclonal antibody against IL-5 (mepolizumab) in patients with several forms of hyper …
