Fc receptors in liver sinusoidal endothelial cells in nzb/w fl lupus mice: a Histological analysis using soluble immunoglobulin g—immune complexes and a monoclonal …
SS Ahmed, H Muro, M Nishimura, I Kosugi, Y Tsutsui… - Hepatology, 1995 - Elsevier
In systemic lupus erythematosus accompanied by the abnormal appearance of circulating
immune complexes (ICs), Fcγ receptor (FcR)-mediated IC handling in macrophages
including Kupffer cells has been shown previously. However, sinusoidal endothelial cells
(SECs) largely ingest soluble immunoglobulin (Ig) G-ICs through FcRs. In this study, the
character, antigenic expression, and activity (ie, ligand-binding capacity of SEC FcRs in
NZB/NZW F1 lupus and NZW nonautoimmune mice) were immunohistochemically analyzed …
immune complexes (ICs), Fcγ receptor (FcR)-mediated IC handling in macrophages
including Kupffer cells has been shown previously. However, sinusoidal endothelial cells
(SECs) largely ingest soluble immunoglobulin (Ig) G-ICs through FcRs. In this study, the
character, antigenic expression, and activity (ie, ligand-binding capacity of SEC FcRs in
NZB/NZW F1 lupus and NZW nonautoimmune mice) were immunohistochemically analyzed …
