[HTML][HTML] Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor
RJ Cenedella, R Jacob, D Borchman, D Tang… - Journal of lipid …, 2004 - ASBMB
Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene
cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage
within a few weeks of treatment. Drug actions, besides reducing the availability of
cholesterol, could contribute to cataract formation. Cholesterol added to cultures of lens
epithelial cells could only partially overcome the growth-inhibiting effects of U18666A. In
view of this finding and the fact that U18666A and other OSC inhibitors are highly lipophilic …
cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage
within a few weeks of treatment. Drug actions, besides reducing the availability of
cholesterol, could contribute to cataract formation. Cholesterol added to cultures of lens
epithelial cells could only partially overcome the growth-inhibiting effects of U18666A. In
view of this finding and the fact that U18666A and other OSC inhibitors are highly lipophilic …
