[HTML][HTML] CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression
CT Fu, JF Bechberger, MA Ozog, B Perbal… - Journal of Biological …, 2004 - ASBMB
Many tumor cells exhibit aberrant gap junctional intercellular communication, which can be
restored by transfection with connexin genes. We have previously discovered that
overexpression of connexin43 (Cx43) in C6 glioma cells not only reduces proliferation but
also leads to production of soluble growth-inhibitory factors. We identified that several
members of the CCN (Cyr61/connective tissue growth factor/nephroblastoma-
overexpressed) family are up-regulated following Cx43 expression, including CCN3 (NOV) …
restored by transfection with connexin genes. We have previously discovered that
overexpression of connexin43 (Cx43) in C6 glioma cells not only reduces proliferation but
also leads to production of soluble growth-inhibitory factors. We identified that several
members of the CCN (Cyr61/connective tissue growth factor/nephroblastoma-
overexpressed) family are up-regulated following Cx43 expression, including CCN3 (NOV) …
