[HTML][HTML] Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells
The gap junction protein connexin43 (Cx43) is thought to be involved in growth control in
several tissues. Using the doxycycline inducible tet-on system, we generated human
malignant trophoblast Jeg3 cells transfected with either Cx40, Cx43, or C-terminal truncated
Cx43 (trCx43). Cx43, but not Cx40 or trCx43, displayed a reduced cell growth of Jeg3 cells
in vitro and tumor growth in nude mice, suggesting a role of the C terminus of Cx43 in growth
regulation. Using gene array analysis, the growth regulator NOV (CCN3), a member of the …
several tissues. Using the doxycycline inducible tet-on system, we generated human
malignant trophoblast Jeg3 cells transfected with either Cx40, Cx43, or C-terminal truncated
Cx43 (trCx43). Cx43, but not Cx40 or trCx43, displayed a reduced cell growth of Jeg3 cells
in vitro and tumor growth in nude mice, suggesting a role of the C terminus of Cx43 in growth
regulation. Using gene array analysis, the growth regulator NOV (CCN3), a member of the …
