[HTML][HTML] Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap …
H Qin, Q Shao, H Curtis, J Galipeau… - Journal of Biological …, 2002 - ASBMB
The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors
remains poorly understood. In this study human breast tumor cells were found to exhibit
diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular
communication (HBL100);(b) low levels of Cx43 and sparse intercellular communication
(MDA-MB-231); and (c) significant levels of Cx43 and moderate intercellular communication
(Hs578T). Although retroviral delivery of Cx43 and Cx26 cDNAs to MDA-MB-231 cells did …
remains poorly understood. In this study human breast tumor cells were found to exhibit
diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular
communication (HBL100);(b) low levels of Cx43 and sparse intercellular communication
(MDA-MB-231); and (c) significant levels of Cx43 and moderate intercellular communication
(Hs578T). Although retroviral delivery of Cx43 and Cx26 cDNAs to MDA-MB-231 cells did …
