Angiotensin II stimulates α-skeletal actin expression in cadiomyocytes in vitro and in vivo in the absence of hypertension
S Clément, C Pellieux, C Chaponnier, T Pedrazzini… - Differentiation, 2001 - Elsevier
Using a specific α-skeletal actin antibody, we have previously shown, that during
hypertension-associated cardiac hypertrophy in the rat, the expression of α-skeletal actin in
the myocardium is increased, but maintains focal distribution, compared to normotensive
animals. In the present study, we have investigated whether α-skeletal actin expression can
be induced in the absence of hypertension. For this purpose, we have examined transgenic
mice overexpressing angiotensinogen exclusively in the heart. These animals are …
hypertension-associated cardiac hypertrophy in the rat, the expression of α-skeletal actin in
the myocardium is increased, but maintains focal distribution, compared to normotensive
animals. In the present study, we have investigated whether α-skeletal actin expression can
be induced in the absence of hypertension. For this purpose, we have examined transgenic
mice overexpressing angiotensinogen exclusively in the heart. These animals are …
