Cx36 involvement in insulin secretion: characteristics and mechanism
P Meda - Cell communication & adhesion, 2003 - Taylor & Francis
P Meda
Cell communication & adhesion, 2003•Taylor & FrancisGap junctions connect the pancreatic β-cells which produce insulin. To investigate their
function, we have first determined that these junctions are made of Cx36. We have then
tested the effect of changing the expression of Cx36, and other connexin isoforms, and have
found that Cx36 modulates insulin secretion. In view of the prominent role of cytosolic Ca2+
in this secretion, we have monitored this cation, and have found that its handling is altered in
populations of insulin-producing cells lacking Cx36. The data identify a first molecular link …
function, we have first determined that these junctions are made of Cx36. We have then
tested the effect of changing the expression of Cx36, and other connexin isoforms, and have
found that Cx36 modulates insulin secretion. In view of the prominent role of cytosolic Ca2+
in this secretion, we have monitored this cation, and have found that its handling is altered in
populations of insulin-producing cells lacking Cx36. The data identify a first molecular link …
Gap junctions connect the pancreatic β-cells which produce insulin. To investigate their function, we have first determined that these junctions are made of Cx36. We have then tested the effect of changing the expression of Cx36, and other connexin isoforms, and have found that Cx36 modulates insulin secretion. In view of the prominent role of cytosolic Ca2+in this secretion, we have monitored this cation, and have found that its handling is altered in populations of insulin-producing cells lacking Cx36. The data identify a first molecular link between Cx36 and the stimulus-secretion pathway leading to insulin secretion.
Taylor & Francis Online