[HTML][HTML] Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption
SJ Choi, SV Reddy, RD Devlin, C Menaa… - Journal of Biological …, 1999 - ASBMB
We screened a human osteoclast (OCL) cDNA expression library for OCL inhibitory factors
and identified a clone that blocked both human and murine OCL formation and bone
resorption by more than 60%. This clone was identical to human legumain, a cysteine
endopeptidase. Legumain significantly inhibited OCL-like multinucleated cell formation
induced by 1, 25-dihydroxyvitamin D 3 (1, 25-(OH) 2 D 3) and parathyroid hormone-related
protein (PTHrP) in mouse and human bone marrow cultures, and bone resorption in the fetal …
and identified a clone that blocked both human and murine OCL formation and bone
resorption by more than 60%. This clone was identical to human legumain, a cysteine
endopeptidase. Legumain significantly inhibited OCL-like multinucleated cell formation
induced by 1, 25-dihydroxyvitamin D 3 (1, 25-(OH) 2 D 3) and parathyroid hormone-related
protein (PTHrP) in mouse and human bone marrow cultures, and bone resorption in the fetal …
