The renin-angiotensin system is a major determinant of arterial pressure and volume
homeostasis in mammals through the actions of angiotensin II, the proteolytic digestion
product of angiotensinogen. Molecular genetic studies in several human populations have
revealed genetic linkage between the angiotensinogen gene and both hypertension and
increased plasma angiotensinogen. Transgenic mice were generated with a human
angiotensinogen genomic clone to develop an animal model to examine tissue-and cell …