Identification of a hypoxia response element in the transferrin receptor gene
CN Lok, P Ponka - Journal of Biological Chemistry, 1999 - ASBMB
Expression of the transferrin receptor, which mediates iron uptake from transferrin, is
negatively regulated post-transcriptionally by intracellular iron through iron-responsive
elements in the 3′-untranslated region of the transferrin receptor mRNA. Transcriptional
mechanisms are also involved in receptor expression, but these are poorly understood. In
this study we have characterized the transferrin receptor promoter region and identified a
functional hypoxia response element that contains a binding site for hypoxia-inducible factor …
negatively regulated post-transcriptionally by intracellular iron through iron-responsive
elements in the 3′-untranslated region of the transferrin receptor mRNA. Transcriptional
mechanisms are also involved in receptor expression, but these are poorly understood. In
this study we have characterized the transferrin receptor promoter region and identified a
functional hypoxia response element that contains a binding site for hypoxia-inducible factor …