Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent
A Naltner, M Ghaffari, JA Whitsett, C Yan - Journal of Biological Chemistry, 2000 - ASBMB
Surfactant B (SP-B) is a 79-amino acid peptide critical to postnatal respiratory adaptation.
Expression of SP-B by respiratory epithelial cells is regulated by developmental and
hormonal influences at the level of gene transcription. Previous studies supported the role of
retinoic acids (RA) and their receptors (RARs) inSP-B gene transcription. In the present
study, RARα was detected in mouse alveolar type II epithelial cells where SP-B is
synthesized and processed. Deletion and site-specific mutagenesis analysis identified …
Expression of SP-B by respiratory epithelial cells is regulated by developmental and
hormonal influences at the level of gene transcription. Previous studies supported the role of
retinoic acids (RA) and their receptors (RARs) inSP-B gene transcription. In the present
study, RARα was detected in mouse alveolar type II epithelial cells where SP-B is
synthesized and processed. Deletion and site-specific mutagenesis analysis identified …