Left and right ventricular collagen type I/III ratios and remodeling post-myocardial infarction
S Wei, LTC Chow, IOL Shum, L Qin… - Journal of cardiac failure, 1999 - Elsevier
Background: Types I and III collagen have different physical properties, and an increase of
type I/III ratio can have a deleterious impact on myocardial compliance and left and right
ventricular diastolic function. Post-myocardial infarction, these changes in collagen types
may be relevant to the remodeling process and the development of heart failure. Methods
and Results: In the rat coronary ligation heart failure model, we studied the time course of
changes in types I and III and total collagen levels over 10 weeks postinfarction. Collagen …
type I/III ratio can have a deleterious impact on myocardial compliance and left and right
ventricular diastolic function. Post-myocardial infarction, these changes in collagen types
may be relevant to the remodeling process and the development of heart failure. Methods
and Results: In the rat coronary ligation heart failure model, we studied the time course of
changes in types I and III and total collagen levels over 10 weeks postinfarction. Collagen …