[HTML][HTML] Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin αvβ3 and …
R Gao, DR Brigstock - Journal of Biological Chemistry, 2004 - ASBMB
Connective tissue growth factor (CCN2, also known as CTGF) is a matricellular protein that
appears to play an important role in hepatic stellate cell (HSC)-mediated fibrogenesis. After
signal peptide cleavage, the full-length CCN2 molecule comprises four structural modules
(CCN2 1–4) and is susceptible to proteolysis by HSC yielding isoforms comprising
essentially modules 3 and 4 (CCN2 3–4) or module 4 alone (CCN2 4). In this study we show
that rat activated HSC are capable of adhesion to all three CCN2 isoforms via the binding of …
appears to play an important role in hepatic stellate cell (HSC)-mediated fibrogenesis. After
signal peptide cleavage, the full-length CCN2 molecule comprises four structural modules
(CCN2 1–4) and is susceptible to proteolysis by HSC yielding isoforms comprising
essentially modules 3 and 4 (CCN2 3–4) or module 4 alone (CCN2 4). In this study we show
that rat activated HSC are capable of adhesion to all three CCN2 isoforms via the binding of …