[HTML][HTML] A potential new role for muscle in blood glucose homeostasis
JJ Shieh, CJ Pan, BC Mansfield, JY Chou - Journal of Biological Chemistry, 2004 - ASBMB
The breakdown of tissue glycogen into glucose is critical for blood glucose homeostasis
between meals. In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-
P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-
6-phosphatase (Glc-6-Pase). Although the majority of body glycogen is stored in the muscle,
the current dogma holds that Glc-6-Pase (now named Glc-6-Pase-α) is expressed only in the
liver, kidney, and intestine, implying that muscle glycogen cannot contribute to interprandial …
between meals. In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-
P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-
6-phosphatase (Glc-6-Pase). Although the majority of body glycogen is stored in the muscle,
the current dogma holds that Glc-6-Pase (now named Glc-6-Pase-α) is expressed only in the
liver, kidney, and intestine, implying that muscle glycogen cannot contribute to interprandial …
