Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
GG Lavery, EA Walker, N Draper, P Jeyasuria… - Journal of Biological …, 2006 - ASBMB
The local generation of active glucocorticoid by NADPH-dependent, 11β-hydroxysteroid
dehydrogenase type 1 (11β-HSD1) oxoreductase activity, has emerged as an important
factor in regulating hepatic glucose output and visceral adiposity. We have proposed that
this NADPH is generated within the endoplasmic reticulum by the enzyme hexose-6-
phosphate dehydrogenase. To address this hypothesis, we generated mice with a targeted
inactivation of the H6PD gene. These mice were unable to convert 11 …
dehydrogenase type 1 (11β-HSD1) oxoreductase activity, has emerged as an important
factor in regulating hepatic glucose output and visceral adiposity. We have proposed that
this NADPH is generated within the endoplasmic reticulum by the enzyme hexose-6-
phosphate dehydrogenase. To address this hypothesis, we generated mice with a targeted
inactivation of the H6PD gene. These mice were unable to convert 11 …
