The newborn of diabetic rat. I. Hormonal and metabolic changes in the postnatal period
JM Cuezva, ES Burkett, DS Kerr, HM Rodman… - Pediatric …, 1982 - nature.com
JM Cuezva, ES Burkett, DS Kerr, HM Rodman, MS Patel
Pediatric Research, 1982•nature.comIn this study we investigated the effects of streptozotocin-induced maternal diabetes on fetal
body weight and alterations in the plasma concentrations of glucose, insulin, glucagon and
catecholamines, and in the concentrations of pancreatic insulin and glucagon and of hepatic
glycogen and cAMP in newborn rats during the first 6 h of life. Hyperglycemia was regulated
in one group of diabetic pregnant rats by administration of insulin twice a day from day 18 of
gestation. On day 22 of gestation the body weight of newborns of the insulin-treated diabetic …
body weight and alterations in the plasma concentrations of glucose, insulin, glucagon and
catecholamines, and in the concentrations of pancreatic insulin and glucagon and of hepatic
glycogen and cAMP in newborn rats during the first 6 h of life. Hyperglycemia was regulated
in one group of diabetic pregnant rats by administration of insulin twice a day from day 18 of
gestation. On day 22 of gestation the body weight of newborns of the insulin-treated diabetic …
Abstract
In this study we investigated the effects of streptozotocin-induced maternal diabetes on fetal body weight and alterations in the plasma concentrations of glucose, insulin, glucagon and catecholamines, and in the concentrations of pancreatic insulin and glucagon and of hepatic glycogen and cAMP in newborn rats during the first 6 h of life. Hyperglycemia was regulated in one group of diabetic pregnant rats by administration of insulin twice a day from day 18 of gestation. On day 22 of gestation the body weight of newborns of the insulin-treated diabetic rats was significantly higher than that of normal rats, whereas untreated maternal diabetes caused a reduction in the body weight of the newborns. The newborns of insulin-treated diabetic rats maintained lower concentrations of plasma glucose for a longer period compared to the age-matched neonates of normal rats.
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