[HTML][HTML] Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling
B Govindarajan, X Bai, C Cohen, H Zhong… - Journal of Biological …, 2003 - ASBMB
Malignant melanoma is the cancer with the most rapid increase in incidence in the United
States. Ultraviolet light and deficiency of the p16ink4a gene are known factors that
predispose one to the development of malignant melanoma. The signal transduction
pathways that underlie the progression of melanoma from their precursors, atypical nevi, are
not well understood. We examined activation of the MAP kinase pathway in atypical nevi
and melanoma cells and found that this pathway is activated in melanomas. To determine …
States. Ultraviolet light and deficiency of the p16ink4a gene are known factors that
predispose one to the development of malignant melanoma. The signal transduction
pathways that underlie the progression of melanoma from their precursors, atypical nevi, are
not well understood. We examined activation of the MAP kinase pathway in atypical nevi
and melanoma cells and found that this pathway is activated in melanomas. To determine …