[PDF][PDF] A genome-based strategy uncovers frequent BRAF mutations in melanoma
PM Pollock, PS Meltzer - Cancer cell, 2002 - cell.com
Cancer cell, 2002•cell.com
A genome-based strategy uncovers frequent BRAF mutations in melanoma Page 1 CANCER
CELL : JULY 2002 5 PREVIEWS The integrity of our organs and tissues is maintained by a
complex network of genes that regulate cellular proliferation, differentiation, and death. Cancers
arise when mutations in key genes cause this network to fail. Based on the age-dependent
kinetics of cancer incidence, it has been estimated that human cancers require 4–6 cooperating
mutations to achieve the fully malignant phenotype (Hahn and Weinberg, 2002). Cancer …
CELL : JULY 2002 5 PREVIEWS The integrity of our organs and tissues is maintained by a
complex network of genes that regulate cellular proliferation, differentiation, and death. Cancers
arise when mutations in key genes cause this network to fail. Based on the age-dependent
kinetics of cancer incidence, it has been estimated that human cancers require 4–6 cooperating
mutations to achieve the fully malignant phenotype (Hahn and Weinberg, 2002). Cancer …
Abstract
Using a genome-scanning approach to search for oncogenes, a recent report identifies somatic mutations in the signaling gene BRAF that are particularly prevalent in melanoma.
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