[HTML][HTML] Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCα in an aldosterone-sensitive manner
W Zhang, X Xia, MR Reisenauer, CS Hemenway… - Journal of Biological …, 2006 - ASBMB
Aldosterone is a major regulator of epithelial Na+ absorption and acts in large part through
induction of the epithelial Na+ channel (ENaC) gene in the renal collecting duct. We
previously identified Dot1a as an aldosterone early repressed gene and a repressor of
ENaCα transcription through mediating histone H3 Lys-79 methylation associated with the
ENaCα promoter. Here, we report a novel aldosterone-signaling network involving AF9,
Dot1a, and ENaCα. AF9 and Dot1a interact in vitro and in vivo as evidenced in multiple …
induction of the epithelial Na+ channel (ENaC) gene in the renal collecting duct. We
previously identified Dot1a as an aldosterone early repressed gene and a repressor of
ENaCα transcription through mediating histone H3 Lys-79 methylation associated with the
ENaCα promoter. Here, we report a novel aldosterone-signaling network involving AF9,
Dot1a, and ENaCα. AF9 and Dot1a interact in vitro and in vivo as evidenced in multiple …