[HTML][HTML] Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
J Schlessinger - Cell, 2002 - cell.com
Cell, 2002•cell.com
The EGF receptor mediates many cellular responses in normal biological processes and in
pathological states. Recent structural studies reveal the molecular basis for ligand binding
specificity and how ligand binding induces receptor dimerization. Receptor dimerization is
mediated by receptor-receptor interactions in which a loop protruding from neighboring
receptors mediates receptor dimerization and activation.
pathological states. Recent structural studies reveal the molecular basis for ligand binding
specificity and how ligand binding induces receptor dimerization. Receptor dimerization is
mediated by receptor-receptor interactions in which a loop protruding from neighboring
receptors mediates receptor dimerization and activation.
Abstract
The EGF receptor mediates many cellular responses in normal biological processes and in pathological states. Recent structural studies reveal the molecular basis for ligand binding specificity and how ligand binding induces receptor dimerization. Receptor dimerization is mediated by receptor-receptor interactions in which a loop protruding from neighboring receptors mediates receptor dimerization and activation.
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