Pathophysiology of synuclein aggregation in Lewy body disease
EB Mukaetova-Ladinska, IG McKeith - Mechanisms of ageing and …, 2006 - Elsevier
We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and
related neurodegenerative disorders that are characterised by intraneuronal accumulation
of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of
synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein
metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-
synuclein mutations and post-translational modifications) and how these influence the …
related neurodegenerative disorders that are characterised by intraneuronal accumulation
of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of
synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein
metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-
synuclein mutations and post-translational modifications) and how these influence the …
