3, 4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
A Carlsson, M Lindqvist, TOR Magnusson - Nature, 1957 - nature.com
A Carlsson, M Lindqvist, TOR Magnusson
Nature, 1957•nature.comTHE depletion by reserpine of storage in the body of 5-hydroxytryptamine ('Serotonin') and
of the catechol amines is now well established1–3. In reserpinized animals the peripheral
part of the adrenergic system does not function owing to lack of the transmitter2. This is
presumably true also of the central part of the adrenergic system. However, it remains to be
proved to what extent the central action of reserpine may be attributed to changes in brain
catechol amines and/or 5-hydroxytryptamine.
of the catechol amines is now well established1–3. In reserpinized animals the peripheral
part of the adrenergic system does not function owing to lack of the transmitter2. This is
presumably true also of the central part of the adrenergic system. However, it remains to be
proved to what extent the central action of reserpine may be attributed to changes in brain
catechol amines and/or 5-hydroxytryptamine.
Abstract
THE depletion by reserpine of storage in the body of 5-hydroxytryptamine (‘Serotonin’) and of the catechol amines is now well established1–3. In reserpinized animals the peripheral part of the adrenergic system does not function owing to lack of the transmitter2. This is presumably true also of the central part of the adrenergic system. However, it remains to be proved to what extent the central action of reserpine may be attributed to changes in brain catechol amines and/or 5-hydroxytryptamine.
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