In vivo localization and pathological effects of passively transferred antibodies to type IV collagen and laminin in mice
G Wick, PU Müller, R Timpl - Clinical Immunology and Immunopathology, 1982 - Elsevier
Injection of rabbit antisera or purified antibodies against the basement membrane proteins
type IV collagen and laminin into inbred mice caused sudden respiratory distress. Tissues
removed 5 and 24 hr later showed hemorrhagic edema and cellular infiltrations particularly
in lung and kidney. Transferred antibodies could be localized by direct immunofluorescence
as smooth, linear staining of a variety of basement membranes including those of glomeruli,
alveoli, choroid plexus, liver, blood vessels, and in the epidermal junction. Injection of …
type IV collagen and laminin into inbred mice caused sudden respiratory distress. Tissues
removed 5 and 24 hr later showed hemorrhagic edema and cellular infiltrations particularly
in lung and kidney. Transferred antibodies could be localized by direct immunofluorescence
as smooth, linear staining of a variety of basement membranes including those of glomeruli,
alveoli, choroid plexus, liver, blood vessels, and in the epidermal junction. Injection of …
