[HTML][HTML] Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers …
Recently an oxygen-sensing/transducing mechanism has been identified as a family of O 2-
dependent prolyl hydroxylase domain-containing enzymes (PHD). In normoxia, PHD
hydroxylates a specific proline residue that directs the degradation of constitutively
synthesized hypoxia-inducible factor-1α. During hypoxia, the cessation of hydroxylation of
this proline results in less degradation and thus increases hypoxia-inducible factor-1α
protein levels. In this study we have examined the consequences of activating the PHD …
dependent prolyl hydroxylase domain-containing enzymes (PHD). In normoxia, PHD
hydroxylates a specific proline residue that directs the degradation of constitutively
synthesized hypoxia-inducible factor-1α. During hypoxia, the cessation of hydroxylation of
this proline results in less degradation and thus increases hypoxia-inducible factor-1α
protein levels. In this study we have examined the consequences of activating the PHD …
