The existence of a number of classes of antidepressant drugs with diverse pharmacological
effects would lead one to expect that antidepressant drugs acting through different
pharmacological mechanisms should produce different behavioral effects. Animal
behavioral tests used to screen antidepressant drugs do not, however, discriminate between
drugs that selectively enhance serotonin or norepinephrine transmission. Several
components of human depression are differently affected by drugs selectively interacting …