The pathophysiology of hepatic steatosis, a prerequisite of nonalcoholic fatty liver disease, is
poorly understood. Because very-low–density lipoprotein (VLDL) formation is the chief route
of hepatic lipid export, we hypothesized that the synthesis of apoB-100, a rate-determining
step in hepatic VLDL formation, may be altered in patients with nonalcoholic steatohepatitis
(NASH). This study evaluated the relative synthesis rates of apolipoprotein B-100 (apoB-
100) in patients with NASH and in lean and body mass index (BMI)–matched (obese) …