[HTML][HTML] Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin: caveolin binding negatively regulates the …
Caveolae are plasma membrane specializations present in most cell types. Caveolin, a 22-
kDa integral membrane protein, is a principal structural and regulatory component of
caveolae membranes. Previous studies have demonstrated that caveolin co-purifies with
lipid modified signaling molecules, including G α subunits, H-Ras, c-Src, and other related
Src family tyrosine kinases. In addition, it has been shown that caveolin interacts directly with
G α subunits and H-Ras, preferentially recognizing the inactive conformation of these …
kDa integral membrane protein, is a principal structural and regulatory component of
caveolae membranes. Previous studies have demonstrated that caveolin co-purifies with
lipid modified signaling molecules, including G α subunits, H-Ras, c-Src, and other related
Src family tyrosine kinases. In addition, it has been shown that caveolin interacts directly with
G α subunits and H-Ras, preferentially recognizing the inactive conformation of these …
