Caveolin-1 interacts with androgen receptor: a positive modulator of androgen receptor mediated transactivation
ML Lu, MC Schneider, Y Zheng, X Zhang… - Journal of Biological …, 2001 - ASBMB
Androgen receptor (AR) belongs to the steroid hormone nuclear receptor superfamily. It
functions as an androgen-dependent transcriptional factor that regulates genes for cell
proliferation and differentiation. Caveolin is a principal component of caveolae membranes
serving as a scaffold protein of many signal transduction pathways. Recent results correlate
caveolin-1 expression with androgen sensitivity in murine prostate cancer. Furthermore,
immunohistochemical staining of patient specimens suggests that caveolin expression may …
functions as an androgen-dependent transcriptional factor that regulates genes for cell
proliferation and differentiation. Caveolin is a principal component of caveolae membranes
serving as a scaffold protein of many signal transduction pathways. Recent results correlate
caveolin-1 expression with androgen sensitivity in murine prostate cancer. Furthermore,
immunohistochemical staining of patient specimens suggests that caveolin expression may …
