Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal bullous disease of the skin
and mucosa characterized by the presence of autoantibodies to type VII collagen, a major
component of anchoring fibrils, structures that help adhere the epidermis onto the dermis.
EBA was classified as an epidermolysis bullosa (EB) disease because clinically it can
resemble hereditary dystrophic forms of EB; yet, it has a different etiology and is an acquired
disease rather than a genetic one.