Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms
TJ Williams, CA Jones, EA Miles, JO Warner… - Journal of allergy and …, 2000 - Elsevier
Background: Cytokine production at the materno-fetal interface may influence the
development of atopy-predisposing immune responses. Because IL-13 possesses IL-4–like
activity and may regulate the immune responses observed in atopy, it may contribute to the
expression of the atopic phenotype initiated during intrauterine life. Objective: We sought to
examine IL-13 expression by fetal and neonatal cells and the placenta. Methods: The
production of IL-13 by neonatal and fetal T cells was examined by culturing the cells in the …
development of atopy-predisposing immune responses. Because IL-13 possesses IL-4–like
activity and may regulate the immune responses observed in atopy, it may contribute to the
expression of the atopic phenotype initiated during intrauterine life. Objective: We sought to
examine IL-13 expression by fetal and neonatal cells and the placenta. Methods: The
production of IL-13 by neonatal and fetal T cells was examined by culturing the cells in the …
