Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene …
K Sugaya, T Fukagawa, K Matsumoto, K Mita… - Genomics, 1994 - Elsevier
K Sugaya, T Fukagawa, K Matsumoto, K Mita, E Takahashi, A Ando, H Inoko, T Ikemura
Genomics, 1994•ElsevierCosmid walking of about 250 kb from MHC class III gene CYP21 to class lI was conducted.
The gene for receptor of advanced glycosylation end products of proteins (RAGE, a member
of immunoglobulin super-family molecules), the PBX2 homeohox gene designated HOXI2,
and the human counterpart of the mouse mammary tumor gene int-3 were found. The
contiguous RAGE and HOX12 genes were completely sequenced, and the human int-3
counterpart was partially sequenced and assigned to a Notch homolog. This human Notch …
The gene for receptor of advanced glycosylation end products of proteins (RAGE, a member
of immunoglobulin super-family molecules), the PBX2 homeohox gene designated HOXI2,
and the human counterpart of the mouse mammary tumor gene int-3 were found. The
contiguous RAGE and HOX12 genes were completely sequenced, and the human int-3
counterpart was partially sequenced and assigned to a Notch homolog. This human Notch …
Abstract
Cosmid walking of about 250 kb from MHC class III gene CYP21 to class lI was conducted. The gene for receptor of advanced glycosylation end products of proteins (RAGE, a member of immunoglobulin super-family molecules), the PBX2 homeohox gene designated HOXI2, and the human counterpart of the mouse mammary tumor gene int-3 were found. The contiguous RAGE and HOX12 genes were completely sequenced, and the human int-3 counterpart was partially sequenced and assigned to a Notch homolog. This human Notch homolog, designated NOTCH3, showed both the intracellular portion present in the mouse int-3 sequence and the extracellular portion absent in the int-3. It thus corresponds to the intact form of a Notch-type transmembrane protein. About 20 kb of dense Alu clustering was found just centromeric to the NOTCH3.
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