The peripheral benzodiazepine receptor ligand PK11195 binds with high affinity to the acute phase reactant α1-acid glycoprotein: implications for the use of the ligand …
A Lockhart, B Davis, JC Matthews, H Rahmoune… - Nuclear medicine and …, 2003 - Elsevier
The peripheral benzodiazepine receptor ligand PK11195 has been used as an in vivo
marker of neuroinflammation in positron emission tomography studies in man. One of the
methodological issues surrounding the use of the ligand in these studies is the highly
variable kinetic behavior of [11C] PK11195 in plasma. We therefore undertook a study to
measure the binding of [3H] PK11195 to whole human blood and found a low level of
binding to blood cells but extensive binding to plasma proteins. Binding assays using [3H] …
marker of neuroinflammation in positron emission tomography studies in man. One of the
methodological issues surrounding the use of the ligand in these studies is the highly
variable kinetic behavior of [11C] PK11195 in plasma. We therefore undertook a study to
measure the binding of [3H] PK11195 to whole human blood and found a low level of
binding to blood cells but extensive binding to plasma proteins. Binding assays using [3H] …