Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
DJ Kane, TA Sarafian, R Anton, H Hahn, EB Gralla… - Science, 1993 - science.org
DJ Kane, TA Sarafian, R Anton, H Hahn, EB Gralla, JS Valentine, T Örd, DE Bredesen
Science, 1993•science.orgThe proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-
2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion.
Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells
depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and
complete survival. Modulation of the increase in reactive oxygen species influenced the
degree of cell death. Yeast mutants null for superoxide dismutase were partially rescued by …
2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion.
Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells
depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and
complete survival. Modulation of the increase in reactive oxygen species influenced the
degree of cell death. Yeast mutants null for superoxide dismutase were partially rescued by …
The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and complete survival. Modulation of the increase in reactive oxygen species influenced the degree of cell death. Yeast mutants null for superoxide dismutase were partially rescued by expression of Bcl-2. Thus, Bcl-2 prevents cell death by decreasing the net cellular generation of reactive oxygen species.
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