The molecular genetics of the arsonate idiotypic system of A/J mice
G Rathbun, I Sanz, K Meek, P Tucker, JD Capra - Advances in immunology, 1988 - Elsevier
Publisher Summary To understand something of the contribution of germline and somatic
events in the generation of a defined immune response, this chapter focuses on the
antibodies produced by A/J mice in response to immunization with the hapten p-
azophenylarsonate. The germline elements that give rise to this response have been
isolated and structurally characterized. The contribution of junctional diversity, N-segment
diversity, and somatic mutation are analyzed in the expressed antibodies. Additionally, the …
events in the generation of a defined immune response, this chapter focuses on the
antibodies produced by A/J mice in response to immunization with the hapten p-
azophenylarsonate. The germline elements that give rise to this response have been
isolated and structurally characterized. The contribution of junctional diversity, N-segment
diversity, and somatic mutation are analyzed in the expressed antibodies. Additionally, the …