Mitochondrial glutathione plays an important role in maintaining a functionally competent
organelle. Previous studies have shown that ethanol feeding selectively depletes the
mitochondrial glutathione pool, more predominantly in mitochondria from perivenous
hepatocytes. Because S-adenosyl-l-methionine (SAM) is a glutathione precursor and
maintains the structure and function of biological membranes, the purpose of the present
study was to determine the effects of SAM on glutathione and function of perivenous (PV) …