Apoptosis triggered by the death receptor CD95 (APO-1 or Fas) is pivotal for the
homeostasis of the immune system. We investigated differential effects of glutathione
depletion on CD95-triggered apoptosis in T and B cell lines as well as the glutathione
dependence of caspase-8 activation. In B lymphoblastoid SKW6. 4 cells, CD95-mediated
apoptosis was prevented upstream of caspase-8 activation and caspase-3-like activity after
acute glutathione depletion by diethyl maleate orcis-chloro-dinitrobenzene …