S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
JM Mato, J Cámara, JF De Paz, L Caballería, S Coll… - Journal of …, 1999 - Elsevier
Background/Aim: The efficacy of S-adenosylmethionine (AdoMet) in the treatment of liver
cell injury has been demonstrated in several experimental models. The aim of this study was
to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis. Methods: A
randomized, double-blind trial was performed in 123 patients treated with AdoMet (1200
mg/day, orally) or placebo for 2 years. All patients had alcoholic cirrhosis, and histologic
confirmation of the diagnosis was available in 84% of the cases. Seventy-five patients were …
cell injury has been demonstrated in several experimental models. The aim of this study was
to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis. Methods: A
randomized, double-blind trial was performed in 123 patients treated with AdoMet (1200
mg/day, orally) or placebo for 2 years. All patients had alcoholic cirrhosis, and histologic
confirmation of the diagnosis was available in 84% of the cases. Seventy-five patients were …