The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains
RW Warren, SA Caster, JB Roths, ED Murphy… - Clinical immunology and …, 1984 - Elsevier
Spontaneous immunoglobulin production in four strains of lpr lpr congenic mice was
investigated to identify genetic interactions in lpr-induced polyclonal B cell activation. Sera
were obtained from male and female lpr lpr mice of the MRL, B6, C3H, and AKR strains as
well as controls of+/+ genotypes. Antibody levels were compared at the time of peak
response. Quantitative antibody determinations were performed by isotype-specific ELISA
assays using responses to single-stranded DNA (sDNA), mouse IgG, rabbit IgG, and …
investigated to identify genetic interactions in lpr-induced polyclonal B cell activation. Sera
were obtained from male and female lpr lpr mice of the MRL, B6, C3H, and AKR strains as
well as controls of+/+ genotypes. Antibody levels were compared at the time of peak
response. Quantitative antibody determinations were performed by isotype-specific ELISA
assays using responses to single-stranded DNA (sDNA), mouse IgG, rabbit IgG, and …
