[HTML][HTML] Activation of the prolactin gene by peroxisome proliferator-activated receptor-α appears to be DNA binding-independent
RM Tolón, AI Castillo, A Aranda - Journal of Biological Chemistry, 1998 - ASBMB
Although the effects of the peroxisome proliferator-activated receptors (PPARs) have been
studied primarily in adipocytes and liver, the wide distribution of these receptors suggests
that they might also play a role in other cell types. We present evidence that PPAR activators
stimulate the expression of the prolactin gene in pituitary GH4C1 cells. Transfection assays
in non-pituitary HeLa cells showed that stimulation of the prolactin promoter by PPARα
requires the presence of the transcription factor GHF-1 (or Pit-1). Proximal promoter …
studied primarily in adipocytes and liver, the wide distribution of these receptors suggests
that they might also play a role in other cell types. We present evidence that PPAR activators
stimulate the expression of the prolactin gene in pituitary GH4C1 cells. Transfection assays
in non-pituitary HeLa cells showed that stimulation of the prolactin promoter by PPARα
requires the presence of the transcription factor GHF-1 (or Pit-1). Proximal promoter …
