Expression of pituitary-tumour transforming gene in colorectal tumours
AP Heaney, R Singson, CJ McCabe, V Nelson… - The Lancet, 2000 - thelancet.com
AP Heaney, R Singson, CJ McCabe, V Nelson, M Nakashima, S Melmed
The Lancet, 2000•thelancet.comBackground Basic fibroblast growth factor promotes angiogenesis and mitogenesis in colon
carcinomas. Pituitarytumour transforming gene (PTTG 1) causes in-vitro and in-vivo
transformation, regulates secretion of basic fibroblast growth factor, and inhibits chromatid
separation. Most normal tissues show little or no PTTG 1 expression but cancer cells
express the gene abundantly. We postulated that PTTG 1 expression in colorectal tumours is
related to tumour invasiveness. Methods PTTG 1 gene and protein expression were …
carcinomas. Pituitarytumour transforming gene (PTTG 1) causes in-vitro and in-vivo
transformation, regulates secretion of basic fibroblast growth factor, and inhibits chromatid
separation. Most normal tissues show little or no PTTG 1 expression but cancer cells
express the gene abundantly. We postulated that PTTG 1 expression in colorectal tumours is
related to tumour invasiveness. Methods PTTG 1 gene and protein expression were …
Background
Basic fibroblast growth factor promotes angiogenesis and mitogenesis in colon carcinomas. Pituitarytumour transforming gene (PTTG1) causes in-vitro and in-vivo transformation, regulates secretion of basic fibroblast growth factor, and inhibits chromatid separation. Most normal tissues show little or no PTTG1 expression but cancer cells express the gene abundantly. We postulated that PTTG1 expression in colorectal tumours is related to tumour invasiveness.
Methods
PTTG1 gene and protein expression were assessed in 68 colorectal tumours and compared with invasive characteristics, such as lymph-node invasion, evidence of metastases, tumour vessel density, and expression of basic fibroblast growth factor. PTTG1 expression is given in terms of the fold-increase over that in normal-adjacent colorectal tissue.
Findings
PTTG1 was overexpressed in all of 48 colon carcinomas (median fold-increase 2·2 [IQR 1·8–3·3]) and in 19 of 20 colonic polyps (2·2 [1·6–3·1]) compared with normal colonic tissue. Invasion of surrounding lymph nodes was associated with higher PTTG1 expression than in carcinomas limited to the bowel wall (3·4 [2·1–5·9] vs 1·9 [1·7–2·4], p=0·007), and higher PTTG1 expression was seen in more vascular than in less vascular tumours (2·6 [1·9–5·1] vs 1·9 [1·8–2·5], p=0·04).
Interpretation
Increased tumour PTTG1 expression may be a marker of invasive colorectal carcinoma and could represent a new therapeutic target.
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