Premature lambs rescued from respiratory failure with natural surfactant: clinical and biophysical correlates
H Jacobs, A Jobe, M Ikegami, T Glatz, SJ Jones… - Pediatric …, 1982 - nature.com
H Jacobs, A Jobe, M Ikegami, T Glatz, SJ Jones, L Barajas
Pediatric research, 1982•nature.comThirty-four Western mixed breed lambs were delivered prematurely at 120 days gestational
age (term= 150 days). Four lambs were sacrificed at birth, and four lambs were sacrificed
with the onset of respiratory failure (P CO 2> 80 torr) at about 30 min of age. The remaining
lambs were treated by tracheal instillation with 50 mg of natural sheep surfactant lipid/kg
body weight. These lambs were sacrificed 10 min, 40 min, 1.5 h and 3 h after surfactant
treatment. Frequent blood gas and compliance measurements documented the clinical …
age (term= 150 days). Four lambs were sacrificed at birth, and four lambs were sacrificed
with the onset of respiratory failure (P CO 2> 80 torr) at about 30 min of age. The remaining
lambs were treated by tracheal instillation with 50 mg of natural sheep surfactant lipid/kg
body weight. These lambs were sacrificed 10 min, 40 min, 1.5 h and 3 h after surfactant
treatment. Frequent blood gas and compliance measurements documented the clinical …
Abstract
Thirty-four Western mixed breed lambs were delivered prematurely at 120 days gestational age (term= 150 days). Four lambs were sacrificed at birth, and four lambs were sacrificed with the onset of respiratory failure (P CO 2> 80 torr) at about 30 min of age. The remaining lambs were treated by tracheal instillation with 50 mg of natural sheep surfactant lipid/kg body weight. These lambs were sacrificed 10 min, 40 min, 1.5 h and 3 h after surfactant treatment. Frequent blood gas and compliance measurements documented the clinical responses of the lambs.
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