A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
AJ De Bold, HB Borenstein, AT Veress, H Sonnenberg - Life sciences, 1981 - Elsevier
AJ De Bold, HB Borenstein, AT Veress, H Sonnenberg
Life sciences, 1981•ElsevierSupernatants of atrial or ventricular myocardial homogenates were injected intravenously
into anaesthetized non-diuretic rats. Extract derived from atrial muscle caused a rapid, more
than 30-fold increase of sodium and chloride excretions, while urine volume rose 10-fold,
and potassium excretion doubled. No such changes were observed after injection of
ventricular tissue extract obtained from the same rat hearts, or after injection of the
homogenization medium. There was no significant difference in glomerular filtration rates …
into anaesthetized non-diuretic rats. Extract derived from atrial muscle caused a rapid, more
than 30-fold increase of sodium and chloride excretions, while urine volume rose 10-fold,
and potassium excretion doubled. No such changes were observed after injection of
ventricular tissue extract obtained from the same rat hearts, or after injection of the
homogenization medium. There was no significant difference in glomerular filtration rates …
Abstract
Supernatants of atrial or ventricular myocardial homogenates were injected intravenously into anaesthetized non-diuretic rats. Extract derived from atrial muscle caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume rose 10-fold, and potassium excretion doubled. No such changes were observed after injection of ventricular tissue extract obtained from the same rat hearts, or after injection of the homogenization medium. There was no significant difference in glomerular filtration rates between the two groups. We conclude that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl reabsorption.
Elsevier
