New (and not so new) antibacterial targets–from where and when will the novel drugs come?
SJ Projan - Current opinion in pharmacology, 2002 - Elsevier
Although the need for new antibacterial therapies and strategies is greater than it has been
in a quarter of a century and despite considerable effort, little progress has been observed in
the development of agents. Target-based screening for new antibacterial agents has been
particularly disappointing, despite a plethora of potential targets, enhanced screening
methodologies and considerable investment. Recent efforts are coalescing around tried and
true biosynthetic pathways like cell wall biosynthesis and the less well exploited pathway for …
in a quarter of a century and despite considerable effort, little progress has been observed in
the development of agents. Target-based screening for new antibacterial agents has been
particularly disappointing, despite a plethora of potential targets, enhanced screening
methodologies and considerable investment. Recent efforts are coalescing around tried and
true biosynthetic pathways like cell wall biosynthesis and the less well exploited pathway for …