Activity of and Resistance to Moxifloxacin in Staphylococcus aureus
D Ince, X Zhang, DC Hooper - Antimicrobial agents and …, 2003 - Am Soc Microbiol
D Ince, X Zhang, DC Hooper
Antimicrobial agents and chemotherapy, 2003•Am Soc MicrobiolMoxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to
select for resistant mutants, and higher bactericidal activity against highly resistant strains
than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and
DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred
target in vivo.
select for resistant mutants, and higher bactericidal activity against highly resistant strains
than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and
DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred
target in vivo.
Abstract
Moxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.
American Society for Microbiology