Differences in proliferation of primary cultures of vascular smooth muscle cells taken from male and female rats
P Travo, G Barrett, G Burnstock - Journal of Vascular Research, 1980 - karger.com
P Travo, G Barrett, G Burnstock
Journal of Vascular Research, 1980•karger.comVascular smooth muscle cells from thoracic aortas of 10-week-old rats were cultured on
different substrates. Cells taken from male animals proliferated more quickly than those
taken from females; this was true for all substrates, but the difference was accentuated by
growth on collagen membranes. The relationship between these results and the sex-linked
incidence of hypertension and atherosclerosis is discussed and a model for future studies
proposed.
different substrates. Cells taken from male animals proliferated more quickly than those
taken from females; this was true for all substrates, but the difference was accentuated by
growth on collagen membranes. The relationship between these results and the sex-linked
incidence of hypertension and atherosclerosis is discussed and a model for future studies
proposed.
Abstract
Vascular smooth muscle cells from thoracic aortas of 10-week-old rats were cultured on different substrates. Cells taken from male animals proliferated more quickly than those taken from females; this was true for all substrates, but the difference was accentuated by growth on collagen membranes. The relationship between these results and the sex-linked incidence of hypertension and atherosclerosis is discussed and a model for future studies proposed.
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