[HTML][HTML] Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of …
J Hallgren, D Spillmann, G Pejler - Journal of Biological Chemistry, 2001 - ASBMB
Mast cell tryptase is stored as an active tetramer in complex with heparin in mast cell
secretory granules. Previously, we demonstrated the dependence on heparin for the
activation/tetramer formation of a recombinant tryptase. Here we have investigated the
structural requirements for this activation process. The ability of heparin-related saccharides
to activate a recombinant murine tryptase, mouse mast cell protease-6 (mMCP-6), was
strongly dependent on anionic charge density and size. The dose-response curve for …
secretory granules. Previously, we demonstrated the dependence on heparin for the
activation/tetramer formation of a recombinant tryptase. Here we have investigated the
structural requirements for this activation process. The ability of heparin-related saccharides
to activate a recombinant murine tryptase, mouse mast cell protease-6 (mMCP-6), was
strongly dependent on anionic charge density and size. The dose-response curve for …
