Blood eosinophils from atopic donors express messenger RNA for the α, β, and γ subunits of the high-affinity IgE receptor (FcϵRI) and intracellular, but not cell surface …
SJ Smith, S Ying, Q Meng, MHF Sullivan… - Journal of allergy and …, 2000 - Elsevier
Background: Blood eosinophils from hypereosinophilic donors were previously reported to
possess the functional high-affinity IgE receptor (FcϵRI), so providing a potential mechanism
to account for eosinophil degranulation in atopic allergic disease. Furthermore, tissue
eosinophils from allergic tissue reactions were shown to be mRNA+ for the α, β, and γ
subunits of FcϵRI and gave positive immunostaining with an anti-FcϵRI-α antibody. Recent
studies, however, revealed negative surface staining on peripheral blood eosinophils, but …
possess the functional high-affinity IgE receptor (FcϵRI), so providing a potential mechanism
to account for eosinophil degranulation in atopic allergic disease. Furthermore, tissue
eosinophils from allergic tissue reactions were shown to be mRNA+ for the α, β, and γ
subunits of FcϵRI and gave positive immunostaining with an anti-FcϵRI-α antibody. Recent
studies, however, revealed negative surface staining on peripheral blood eosinophils, but …
