Expression and modulation of FcϵRIα and FcϵRIβ in human blood basophils
SS Saini, JJ Richardson, C Wofsy… - Journal of allergy and …, 2001 - Elsevier
Background: The IgE receptor (FcϵRI) may exist as a tetramer (αβγ2) or a trimer (αγ2)
because FcϵRIβ is dispensable for membrane expression of FcϵRIα. FcϵRIβ amplifies
signaling of FcϵRI so that regulation of FcϵRIα: β stoichiometry would affect cellular
responsiveness. Objective: We examined basophils from a variety of donors for differences
in their expression of FcϵRIα and FcϵRIβ protein. Methods: Enriched blood basophils were
assessed at baseline and after IL-3 culture for FcϵRIα and FcϵRIβ protein by Western …
because FcϵRIβ is dispensable for membrane expression of FcϵRIα. FcϵRIβ amplifies
signaling of FcϵRI so that regulation of FcϵRIα: β stoichiometry would affect cellular
responsiveness. Objective: We examined basophils from a variety of donors for differences
in their expression of FcϵRIα and FcϵRIβ protein. Methods: Enriched blood basophils were
assessed at baseline and after IL-3 culture for FcϵRIα and FcϵRIβ protein by Western …
