[HTML][HTML] A rat kidney-specific calcium transporter in the distal nephron
JB Peng, XZ Chen, UV Berger, PM Vassilev… - Journal of Biological …, 2000 - ASBMB
Active absorption of calcium from the intestine and reabsorption of calcium from the kidney
are major determinants of whole body calcium homeostasis. Two recently cloned proteins,
CaT1 and ECaC, have been postulated to mediate apical calcium uptake by rat intestine
and rabbit kidney, respectively. By screening a rat kidney cortex library with a CaT1 probe,
we isolated a cDNA encoding a protein (CaT2) with 84.2 and 73.4% amino acid identities to
ECaC and CaT1, respectively. Unlike ECaC, CaT2 is kidney-specific in the rat and was not …
are major determinants of whole body calcium homeostasis. Two recently cloned proteins,
CaT1 and ECaC, have been postulated to mediate apical calcium uptake by rat intestine
and rabbit kidney, respectively. By screening a rat kidney cortex library with a CaT1 probe,
we isolated a cDNA encoding a protein (CaT2) with 84.2 and 73.4% amino acid identities to
ECaC and CaT1, respectively. Unlike ECaC, CaT2 is kidney-specific in the rat and was not …
